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Dose proportionality study of loperamide following oral administration of loperamide oxide
F Kamali1, L Adriaens, M L Huang
1Wolfson Unit of Clinical Pharamcology, The University, Newcastle upon Tyne, UK.
European Journal of Clinical Pharmacology
|January 1, 1992
Abstract:
The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.