Related Experiment Video
Updated: Aug 15, 2026

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Published on: June 1, 2022
Mathematical modeling of mitochondrial adenine nucleotide translocase
Eugeniy Metelkin1, Igor Goryanin, Oleg Demin
1A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov, Moscow State University, Moscow, Russia. metelkin@insysbio.ru
Abstract:
We have developed a mathematical model of adenine nucleotide translocase (ANT) function on the basis of the structural and kinetic properties of the transporter. The model takes into account the effect of membrane potential, pH, and magnesium concentration on ATP and ADP exchange velocity. The parameters of the model have been estimated from experimental data. A satisfactory model should take into account the influence of the electric potential difference on both ternary complex formation and translocation processes. To describe the dependence of translocation constants on electric potential we have supposed that ANT molecules carry charged groups. These groups are shifted during the translocation. Using the model we have evaluated the translocator efficiency and predicted the behavior of ANT under physiological conditions.
More Related Videos
Related Concept Videos
Energy to Drive Translocation
Generally, polypeptides are unfolded by two distinct...
ATP Synthase: Mechanism
The ADP/ATP Carrier Protein
Protein Transport into the Inner Mitochondrial Membrane
Transport of mitochondrial precursors across the TIM23 channel is driven by...
ATP Synthase: Structure
Translocation of Proteins into the Mitochondria
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...

