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Updated: Jul 31, 2026
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Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat
Published on: February 7, 2011
Insulin infusion protocol for critical care units.
Dimple Dilkhush1, Jeffry Lannigan, Tressa Pedroff
1Department of Pharmacy, Bayfront Medical Center (BMC), St. Petersburg, FL 33701, USA. dimple.dilkhush@bayfront.org
Summary
A new insulin infusion protocol for critical care units was developed to improve glycemic control. This protocol safely and effectively managed blood glucose levels in critically ill patients, minimizing hypoglycemia.
Area of Science:
- Critical Care Medicine
- Endocrinology
- Pharmacology
Background:
- Elevated blood glucose in critical care is a significant concern.
- Existing insulin infusion practices were often delayed and lacked standardized adjustments.
- Aggressive glycemic control is recognized to improve patient outcomes.
Purpose of the Study:
- To describe the development and implementation of a novel insulin infusion protocol for critical care units.
- To establish a standardized approach for managing hyperglycemia in critically ill patients.
Main Methods:
- A multidisciplinary team (physicians, nurses, dietitians, pharmacists) collaborated to create the protocol.
- The protocol targeted a blood glucose range of 80-130 mg/dL with specific insulin dosage adjustment guidelines.
- Data from the first 30 patients were collected and analyzed.
Main Results:
- The protocol successfully reduced blood glucose to <130 mg/dL within a mean of 12.6 hours.
- Out of 2,845 measurements, only 15 instances (0.4%) of hypoglycemia occurred, requiring treatment.
- The protocol demonstrated effective and safe glycemic management.
Conclusions:
- A multidisciplinary approach led to the successful development of an insulin infusion protocol for critical care.
- The protocol provides a standardized, evidence-based method for managing blood glucose in critically ill patients.
- The protocol is associated with a low incidence of hypoglycemia.
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