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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
Immunization with recombinant Streptococcus pneumoniae neuraminidase NanA protects chinchillas against nasopharyngeal
1Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Room 4331 Cramblett Hall, 456 W. 10th Ave., Columbus, OH 43210, USA.
Infection and Immunity
|October 22, 2005
Abstract:
Immunization with recombinant S. pneumoniae neuraminidase NanA (rNanA) resulted in a significant reduction in pneumococcal colonization in the chinchilla model. The bacteria were eliminated from the nasopharynx 1 week earlier than that from the control cohort. Our data suggest that rNanA affords protection against pneumococcal nasopharyngeal colonization.

