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Related Experiment Videos

Quantitative upper airway imaging with anatomic optical coherence tomography.

Julian J Armstrong1, Matthew S Leigh, David D Sampson

  • 1Optical+Biomedical Engineering Laboratory, School of Electrical, Electronic, and Computer Engineering, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009. julian-a@ee.uwa.edu.au

American Journal of Respiratory and Critical Care Medicine
|October 22, 2005
PubMed
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Anatomic optical coherence tomography (aOCT) offers a minimally invasive, real-time method for imaging upper airway anatomy. This technique provides quantitative data comparable to CT scans, aiding obstructive sleep apnea research and treatment.

Area of Science:

  • Medical Imaging
  • Otolaryngology
  • Sleep Medicine

Background:

  • Accurate measurement of upper airway dimensions is crucial for understanding obstructive sleep apnea (OSA) pathophysiology.
  • Current imaging techniques may have limitations in real-time, in-vivo assessment during sleep.
  • Anatomic optical coherence tomography (aOCT) is introduced as a novel endoscopic optical technique for quantitative imaging.

Purpose of the Study:

  • To describe and validate a novel endoscopic optical technique, aOCT, for quantitative real-time imaging of the upper airway.
  • To compare aOCT measurements with established computed tomography (CT) methods.
  • To assess the utility of aOCT in studying upper airway dynamics during sleep, particularly in the context of OSA.

Main Methods:

  • aOCT was validated by comparing cross-sectional area (CSA) measurements with CT-derived data in a wax phantom and in the pharyngeal regions (velopharynx, oropharynx, hypopharynx) of five awake volunteers.

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  • aOCT scanning was also performed during sleep in one participant diagnosed with OSA.
  • Quantitative imaging of airway dimensions and shape changes was performed.

    • Main Results:

    • aOCT provided quantitative measurements of pharyngeal shape and CSA comparable to CT.
    • In the wax phantom, aOCT and CT CSA measurements showed high agreement (ICC=0.99).
    • In the pharyngeal airway, aOCT and CT CSA measurements also demonstrated good agreement (ICC=0.89), with a mean difference of 14.1 mm².
    • aOCT successfully captured dynamic changes in upper airway size and shape during and around an apneic event in the OSA subject.

    Conclusions:

    • aOCT is a minimally invasive technique that yields quantitative, real-time measurements of upper airway size and shape.
    • Its ability to study airway behavior over extended periods during both sleep and wakefulness makes it valuable.
    • aOCT shows significant potential for advancing OSA pathophysiology research and improving clinical management strategies.