The second human beta B2-crystallin gene is a pseudogene
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R H Brakenhoff1, H J Aarts, F Schuren
1Laboratory for Molecular Biology, University of Nijmegen, The Netherlands.
Experimental Eye Research
|May 1, 1992
Abstract:
Comparison of the partial sequences of the human beta B2-1- and beta B2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human beta B2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the beta B2-2-crystallin gene could be detected in the human lens. These data suggest that the human beta B2-2-crystallin gene is a pseudogene.