Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular morphogenesis in the primate ovary.

Hamish M Fraser1, W Colin Duncan

  • 1MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK. h.fraser@hrsu.mrc.ac.uk

Angiogenesis
|October 22, 2005
PubMed
Summary

Vascular Endothelial Growth Factor (VEGF) is crucial for ovarian angiogenesis and function. Inhibiting VEGF disrupts follicular growth, ovulation, and corpus luteum development, impacting reproductive health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effects of Hormone Changes over the Menstrual Cycle on Elite Athlete Performance: Meta-analysis and Suggested Standardised Protocol.

Reproduction & fertility·2026
Same author

Estrus monitoring in giant pandas revisited: The importance of assay selection.

Animal reproduction science·2026
Same author

An ovine model shows that subcutaneous adipose tissue fibrosis occurs early in polycystic ovary syndrome (PCOS).

Journal of molecular endocrinology·2025
Same author

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women.

Clinical endocrinology·2025
Same author

Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS).

Molecular and cellular endocrinology·2024
Same author

Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation.

Frontiers in endocrinology·2023

Area of Science:

  • Reproductive Biology
  • Vascular Biology
  • Endocrinology

Background:

  • Ovarian function relies on dynamic blood vessel formation and breakdown.
  • Understanding the molecular mechanisms of ovarian angiogenesis is essential.

Purpose of the Study:

  • To investigate the physiological role of vascular endothelial growth factor (VEGF) in ovarian angiogenesis.
  • To determine the effects of VEGF inhibition on follicular and luteal development in marmosets.

Main Methods:

  • Quantified angiogenesis during follicular maturation and corpus luteum phases in marmosets.
  • Administered VEGF antagonists during specific stages of the ovarian cycle in vivo.
  • Assessed effects on endothelial and granulosa cell proliferation, follicular growth, ovulation, and progesterone levels.

Main Results:

  • VEGF inhibition during the follicular phase reduced endothelial and granulosa cell proliferation, restricted follicular growth, and inhibited ovulation.
  • VEGF inhibition during the luteal phase significantly suppressed angiogenesis, microvascular development, and progesterone production.
  • VEGF is demonstrated as essential for both follicular and luteal angiogenesis and ovarian function.

Conclusions:

  • Vascular Endothelial Growth Factor (VEGF) is indispensable for normal ovarian angiogenesis and function.
  • Luteal angiogenesis serves as a sensitive indicator for evaluating angiogenic antagonists.
  • VEGF antagonists are valuable tools for studying ovarian angiogenic factors and may aid in treating reproductive disorders.

Related Experiment Videos