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Updated: Aug 15, 2026

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
Cardiac pathology in status epilepticus
Edward M Manno1, Eric A Pfeifer, Gregory D Cascino
1Department of Neurology W8B, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. manno.edward@mayo.edu
Abstract:
Massive catecholamine release resulting in the formation of cardiac contraction bands may represent the cause of death in status epilepticus (SE). We reviewed the cardiac pathology of patients who died during SE to asses for contraction bands. Eight of 11 patients who died during SE had identifiable myocardial contraction bands compared with 5 of 22 control patients (p < 0.05, Fisher's exact t test). These findings delineate a pathological substrate and provide compelling evidence that excessive catecholamine release is the mechanism responsible for death in SE.
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