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Related Experiment Videos

Cardiac pathology in status epilepticus.

Edward M Manno1, Eric A Pfeifer, Gregory D Cascino

  • 1Department of Neurology W8B, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. manno.edward@mayo.edu

Annals of Neurology
|October 22, 2005
PubMed
Summary

Massive catecholamine release may cause death in status epilepticus (SE). Cardiac pathology in SE patients revealed myocardial contraction bands, supporting this mechanism.

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Area of Science:

  • Cardiovascular Pathology
  • Neurology
  • Forensic Medicine

Background:

  • Status epilepticus (SE) is a neurological emergency.
  • The exact cause of death in SE is not fully understood.
  • Massive catecholamine release is a suspected factor.

Purpose of the Study:

  • To investigate the presence of myocardial contraction bands in patients who died during SE.
  • To determine if catecholamine release is a pathological substrate for mortality in SE.

Main Methods:

  • Retrospective review of cardiac pathology.
  • Comparison of myocardial contraction band prevalence between SE decedents and controls.
  • Fisher's exact t test for statistical analysis.

Main Results:

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  • Myocardial contraction bands were identified in 8 of 11 patients who died during SE.
  • This prevalence was significantly higher than in 5 of 22 control patients (p < 0.05).

Conclusions:

  • Findings provide pathological evidence linking SE to cardiac events.
  • Excessive catecholamine release is implicated as the mechanism of death in SE.
  • Myocardial contraction bands serve as a pathological marker.