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Related Experiment Videos

Diazepam tolerance effects on vestibular function testing, part II: vestibulo-ocular reflex parameters during

Patricia A Blau1, Nathan Schwade, Peter Roland

  • 1Dept of Otorhinolaryngology, University of Texas Southwestern Medical Center at Dallas, TX 75390-8876, USA.

The Annals of Otology, Rhinology, and Laryngology
|October 26, 2005
PubMed
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Clinical doses of diazepam (DZ) did not cause tolerance in the vestibulo-ocular reflex (VOR) as measured by the sinuosidal harmonic acceleration (SHA) rotational test. This suggests patients may not need to stop DZ before SHA testing.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Repeated diazepam (DZ) administration is known to cause tolerance in memory, sedation, and psychomotor tasks.
  • The effect of DZ on the vestibulo-ocular reflex (VOR) has not been previously established.

Purpose of the Study:

  • To determine if clinical doses of diazepam (10 mg/d for 14 days) induce tolerance in the VOR using the sinuosidal harmonic acceleration (SHA) rotational test.

Main Methods:

  • A double-blinded, repeated-measures study involving 30 healthy males aged 20-36.
  • Subjects were randomized to placebo or DZ groups, undergoing 6 SHA rotational sessions over 2 weeks.
  • Analysis utilized a 1-way ANOVA to compare percent change from baseline between groups.

Main Results:

  • Significant differences (p < .05) in VOR gain and phase were observed at lower frequencies (0.01–0.08 Hz) between treatment groups.

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  • No significant effects on gain or phase were found at 0.16 Hz, indicating selective central nervous system effects.
  • No time-dependent significance was observed, suggesting tolerance did not develop over the study period.

    • Conclusions:

    • Diazepam at clinical doses did not induce tolerance in the VOR as measured by the SHA test.
    • DZ group scores remained within normal ranges for VOR phase and gain.
    • Patients on diazepam may not need to discontinue the medication before undergoing SHA rotational testing, especially if drug cessation is problematic.