Related Experiment Videos
Chromosome segregation from cell hybrids. VII. Reverse segregation from karyoplast hybrids suggests control by
1Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
Genome
|June 1, 1992
Abstract:
Using human and Chinese hamster established lines as cell parents, we constructed hamster-human cell hybrids and human cell - hamster karyoplast hybrids. The cell hybrids retained one or two sets of hamster chromosomes and lost most of the human chromosomes. The karyoplast hybrids, however, retained a full set of human chromosomes and lost most of the Chinese hamster chromosomes. This reverse segregation pattern implies that cytoplasmic factors are major determinants of the direction of chromosome segregation.