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Updated: Aug 15, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Reduced pulsatility does not explain renal hyporesponsiveness to cardiac natriuretic peptides in pulmonary
Anne Charloux1, Ari Chaouat, Gabrielle Brandenberger
1Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l'Homme, Institut de Physiologie, 4 rue Kirschleger, 67085 Strasbourg Cedex, France. Anne.Charloux@chru-strasbourg.fr
Abstract:
A pulsatile secretory pattern is assumed to improve hormonal efficiency. We examined the short-term time courses of circulating atrial (ANP) and brain natriuretic peptides (BNP) in patients with pulmonary hypertension (PH) and reduced renal efficiency of ANP-BNP, reflected by low natriuresis/ANP or BNP ratios. Compared to controls, we observed a persistence of ANP and BNP pulsatility in PH patients with a similar periodicity of 20min. Pulse amplitude increased proportionally to the rise in mean plasma level observed in patients (around 27%). In PH patients, the decrease in ANP-BNP renal efficiency is not attributable to a loss of the rhythmic pulsatility of these hormones.
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