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Basal cell carcinomas with unusual histologic patterns.

Angela C S Hutcheson1, Ann Harriott Fisher, Pearon G Lang

  • 1Department of Dermatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

Journal of the American Academy of Dermatology
|October 26, 2005
PubMed
Summary
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This case series highlights rare basal cell carcinoma (BCC) variants. It details two cases with a trabecular growth pattern, a previously unreported BCC histologic feature.

Area of Science:

  • Dermatopathology
  • Histopathology
  • Oncology

Background:

  • Basal cell carcinoma (BCC) is the most common skin cancer.
  • Uncommon BCC histologic variants pose diagnostic challenges.
  • Accurate diagnosis is crucial for appropriate treatment.

Purpose of the Study:

  • To describe unusual histologic variants of basal cell carcinoma (BCC).
  • To report on two cases of BCC with a trabecular growth pattern.
  • To document one case of BCC with apocrine differentiation.

Main Methods:

  • Case series of three patients with unusual BCCs.
  • Histologic examination of formalin-fixed, paraffin-embedded specimens.
  • Use of hematoxylin and eosin staining, plus special stains (PAS-D, colloidal iron, CEA, CK20).

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Main Results:

  • One BCC case showed apocrine differentiation.
  • Two BCC cases exhibited a trabecular growth pattern.
  • The trabecular growth pattern in BCC is a novel finding.

Conclusions:

  • Uncommon BCC variants require careful histologic evaluation.
  • Trabecular growth pattern is a newly identified BCC histologic feature.
  • Further research is needed to understand the clinical significance of these variants.