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A binding free energy hot spot in the ankyrin repeat protein GABPbeta mediated protein-protein interaction

Daniel C Desrosiers1, Zheng-yu Peng

  • 1Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06032, USA. desrosiers@student.uchc.edu

Journal of Molecular Biology
|October 26, 2005
PubMed

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Conserved Binding Sites01:49

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
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