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Testicular feminization syndrome in a mare
B G Crabbe1, D A Freeman, B D Grant
1Department of Veterinary Clinical Medicine and Surgery, College of Veterinary Medicine, Washington State University, Pullman 99164-6610.
Summary
Testicular feminization syndrome in a mare caused aggressive behavior and infertility due to undescended testicles. Surgical removal resolved the symptoms, revealing a male karyotype.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Genetics
Background:
- Testicular feminization syndrome (TFS) is a rare condition involving androgen insensitivity during development.
- It leads to the development of normal female external genitalia despite the presence of male gonads and high testosterone levels.
Observation:
- A mare presented with aggressive, stallion-like behavior and infertility.
- Ultrasonography revealed ovarian-like structures consistent with testicular tissue.
- The mare had a blind vaginal ending, absent cervix, and uterus, along with high testosterone levels.
Findings:
- Surgical removal of hypoplastic testicles was performed.
- Chromosomal analysis confirmed a 64X,Y karyotype (normal male).
- Post-surgery, the mare's aggressive behavior completely resolved.
Implications:
- This case highlights TFS as a crucial differential diagnosis for aggressive, infertile mares.
- Understanding androgen receptor abnormalities is key to diagnosing and managing TFS in equine patients.
- Successful surgical intervention can resolve behavioral issues and confirm the diagnosis.