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Incidence of pleural mesothelioma in Liguria Region, Italy (1996-2002)

V Gennaro1, D Ugolini, P Viarengo

  • 1Liguria Regional Operating Center (COR) of the National Mesothelioma Registry (ReNaM), Department of Epidemiology and Prevention, National Cancer Research Institute, Largo R. Benzi 10, 16132 Genova, Italy. valerio.gennaro@istge.it

European Journal of Cancer (Oxford, England : 1990)
|October 26, 2005
PubMed

Insights

Environmental asbestos exposure is linked to a higher incidence of pleural malignant mesothelioma (PMM) in Italy's Liguria Region. This study investigated PMM cases and identified industrial areas as high-risk zones, especially for females.

Area of Science:

  • Environmental Health
  • Epidemiology
  • Occupational Medicine

Background:

  • Pleural malignant mesothelioma (PMM) is a significant asbestos-related cancer.
  • Investigating PMM incidence requires understanding local asbestos exposure risks.
  • The Liguria Region in Italy has a history of industrial and harbour activities.

Purpose of the Study:

  • To investigate the incidence of pleural malignant mesothelioma (PMM) in the Liguria Region.
  • To analyze the demographic and etiological characteristics of PMM cases.
  • To explore the role of asbestos exposure in PMM development within the region.

Main Methods:

  • Analysis of new PMM cases recorded by the Mesothelioma Registry of Liguria (1996-2002).
  • Interviews using a standardized questionnaire for 786 PMM cases or next-of-kin.
  • Age-standardized incidence rates calculated per 100,000 inhabitants (European population).

Main Results:

  • 945 PMM cases were recorded (757 males, 188 females).
  • Higher incidence rates were observed in provinces with significant industrial, harbour, and shipyard activities.
  • Asbestos exposure was unlikely or unknown for 57.5% of females and 15% of males.

Conclusions:

  • Environmental asbestos exposure is hypothesized to play a major role in PMM etiology, particularly in females.
  • Industrial and harbour areas are associated with increased PMM incidence.
  • Further investigation into environmental asbestos exposure is warranted for both genders.

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