Vaccines based on Nef and on Nef/DeltaV2 Env
Related Experiment Video
Updated: Aug 15, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
Volker Erfle1, Frank D Goebel, Carlos A Guzman
1Institute of Molecular Virology, GSF-National Research Center for Environment and Health, Ingolstaedter Landstrasse 1a, 85764 Neuherberg, Germany. erfle@gsf.de
Abstract:
Modified vaccinia virus Ankara (MVA) is a potent vaccine vector, which proved its safety, immunogenity and efficacy in preclinical and clinical studies. The rational for the development of a vaccine against HIV based on the regulatory protein Nef delivered by MVA combined with a V2-deleted Env protein is discussed.
Related Concept Videos
Vaccines
Vaccinations
Vaccine Production
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Encephalitis ll: Pathophysiology

