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Updated: Aug 4, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
The priming/completion paradigm to explain growth factor-dependent cell cycle progression
1Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA. kazlauskas@vision.eri.harvard.edu
Abstract:
Approximately 50 years ago, researchers established conditions to maintain cells in tissue culture: Likely et al. (1952), Scherer et al. (1953), Eagle (1955). This simple model system set the stage for discovery of growth factors and the signaling systems that they engage to mediate cellular responses such as proliferation. The purpose of this review is to present the original view of how growth factors regulate cell cycle progression and an updated (priming/completion) version of how growth factors advance resting cells through the cell cycle.
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