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A new anthelmintic cyclodepsipeptide, PF1022A
T Sasaki1, M Takagi, T Yaguchi
1Pharmaceutical Research Laboratories, Meiji Seika Kaisha Ltd., Yokohama, Japan.
The Journal of Antibiotics
|May 1, 1992
Abstract:
The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (FERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-meth ylleucyl-D-lactyl-L-N- methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.