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Updated: Aug 7, 2026

Two-Dimensional X-Ray Angiography to Examine Fine Vascular Structure Using a Silicone Rubber Injection Compound
Published on: January 7, 2019
CT angiography is here--are we expected to see a change of angiography referral pattern?
1Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. aroguin@technion.ac.il
Insights
A patient with cardiac risk factors had a normal nuclear stress test but CT angiography revealed coronary artery disease (CAD), leading to stenting. This case highlights how advanced imaging can change CAD diagnosis and treatment decisions.
Area of Science:
- Cardiology
- Diagnostic Imaging
Background:
- Coronary artery disease (CAD) diagnosis relies on various imaging modalities.
- Risk factors for CAD include hypertension, diabetes, hypertriglyceridemia, obesity, and family history.
Observation:
- A 52-year-old asymptomatic male with multiple cardiac risk factors underwent a nuclear stress test.
- The nuclear stress test was normal, showing no signs of ischemia or ECG changes.
- Despite the normal stress test, the patient pursued further imaging due to anxiety.
Findings:
- CT angiography revealed significant coronary narrowings, contradicting the nuclear stress test results.
- Coronary angiography confirmed the findings from CT angiography, identifying treatable lesions.
- The patient's coronary narrowings were successfully treated with stents.
Implications:
- CT angiography can detect significant coronary artery disease (CAD) in cases where traditional stress tests are inconclusive.
- Advanced imaging technologies like CT angiography are crucial in refining the diagnosis of CAD.
- The findings suggest a potential shift in diagnostic algorithms for CAD, incorporating CT angiography earlier in select patient populations.
Abstract:
A 52-year-old asymptomatic man, with cardiac risk factors of hypertension, Type II diabetes, hypertriglyceridemia, low HDL, obesity, and positive family history for early coronary artery disease (CAD), was referred to nuclear stress test. He exercised for 14 minutes, achieved his target heart rate, without any symptoms or ECG changes. Nuclear images were entirely normal. However, the patient was still concerned and anxious so he underwent CT angiography that revealed coronary narrowings. Next, he underwent coronary angiography with similar findings. The lesions were treated with stents. We present a case report to illustrate how newer technology such as CT angiography alters the way in which we diagnose CAD and decide on whether to pursue further invasive therapy.
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