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Updated: Aug 15, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
Hypoxic-ischemic encephalopathy in infants: new challenges
Maria Gieron-Korthals1, José Colón
1University of South Florida, College of Medicine, Tampa, Florida 33606, USA. mgieronk@hsc.usf.edu
Abstract:
The subject of hypoxic-ischemic encephalopathy (HIE) is hardly new and yet remains an every day challenge to clinicians, mainly neonatologists and child neurologists. However, technological advances in neuroimaging do help in the diagnosis, but prevention of hypoxic-ischemic insults, ability to change the course of the disease, and treatment of the devastating consequences of HIE are lagging behind. With these issues in mind, we reviewed the literature on this subject and our own clinical experience in search of new developments in this area. The pathology and clinicopathologic correlates of HIE are emphasized as well.
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