Interleukin-6 genetic polymorphism and Chinese major depression
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Chen-Jee Hong1, Younger W-Y Yu, Tai-Jui Chen
1Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Background:
It has been reported that serum concentrations of interleukin-6 (IL-6), a pro-inflammatory cytokine, were significantly higher in major depressive disorder (MDD).
Objectives:
The aim of the present study was to examine whether the IL-6 genetic variant confers susceptibility to MDD.
Methods:
We genotyped a functional polymorphism in the promoter region (position -634) of the IL-6 gene in a sample of 257 MDD patients and 105 normal controls.
Results:
No significant differences were demonstrated for the genotype or allele frequency of the IL-6 polymorphism when comparing the MDD and control groups.
Conclusions:
Our findings suggested that the investigated IL-6 polymorphism does not affect MDD susceptibility. We propose that other genetic variations of IL-6, relating either to MDD or to the clinical manifestations of MDD, may need further investigation.
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