Related Experiment Video

Updated: Aug 15, 2026

Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

[Recurrent Miller-Fisher syndrome]

F Battaglia1, F Attane, A Robinson

  • 1Service de Neurologie, Centre Hospitalier A. Gayraud, Carcassonne. fabrice.battaglia@ch-carcassonne.fr

Revue Neurologique
|October 26, 2005
PubMed
Abstract

Insights

Recurrent Miller-Fisher syndrome (MFS) is exceptionally rare. This case highlights unusual clinical, biological, and electrophysiological features in a patient with two MFS episodes over 19 years.

Area of Science:

  • Neurology
  • Autoimmune Disorders

Background:

  • Miller-Fisher syndrome (MFS) is a rare autoimmune post-infectious neurological disorder.
  • It is characterized by ataxia, ophthalmoplegia, and areflexia, often considered a variant of Guillain-Barré syndrome (GBS).
  • MFS is typically associated with anti-GQ1b antibodies and electrophysiological abnormalities.

Observation:

  • A 54-year-old woman experienced two episodes of MFS over 19 years.
  • The first episode presented as classical MFS, while the second was extensive, involving tetraparesis and respiratory failure.
  • This patient had normal CSF protein levels and brain MRI findings.

Findings:

  • The patient exhibited strongly positive anti-GQ1b antibodies and slightly positive anti-GM1/anti-GM2 antibodies.
  • Electromyography revealed isolated sensory abnormalities in the median nerve territory.
  • Campylobacter jejuni serology was negative, ruling out a common trigger.

Implications:

  • This case expands the understanding of recurrent MFS, demonstrating unusual clinical presentations.
  • It underscores the importance of considering atypical features in recurrent MFS diagnosis.
  • The findings contribute to the literature on the variable clinical and biological spectrum of MFS.

More Related Videos

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Related Concept Videos

Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.