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Related Experiment Videos

Hypercoagulant states in malignant lymphoma.

H Wada1, T Sase, M Yamaguchi

  • 1Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Japan. wadahide@clin.medic.mie-u.ac.jp

Experimental Oncology
|October 26, 2005
PubMed
Summary

Disseminated intravascular coagulation (DIC) in lymphoma, particularly stage IV or natural killer (NK) cell types, is linked to abnormal clotting. Chemotherapy can increase tissue factor (TF) and inflammatory markers, potentially activating leukocytes.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Disseminated intravascular coagulation (DIC) is a severe complication in malignant lymphoma, with higher incidence in stage IV or natural killer (NK) cell lymphoma.
  • Patients with advanced or NK cell lymphoma often present with abnormal thrombotic and hemostatic states.
  • Elevated cytokine expression by lymphoma cells may stimulate tissue factor (TF) expression, contributing to DIC mechanisms.

Purpose of the Study:

  • To investigate the relationship between chemotherapy, tissue factor (TF) expression, and coagulation abnormalities in lymphoma patients.
  • To explore the role of inflammatory markers and leukocyte activation during lymphoma treatment.

Main Methods:

  • Monitoring white blood cell counts, leukocyte TF mRNA levels, and plasma concentrations of granulocyte elastase derived-XDP (GE-XDP) and D-dimer during chemotherapy.

Related Experiment Videos

  • Analyzing correlations between TF mRNA, GE-XDP, D-dimer, C-reactive protein (CRP), and leukocyte counts in patients with DIC or ARDS.

    • Main Results:

    • Leukocyte TF mRNA levels significantly increased at day 7 of chemotherapy.
    • Plasma GE-XDP levels correlated with D-dimer levels, indicating GE-XDP as a major contributor to elevated D-dimer.
    • CRP, GE-XDP, and D-dimer were elevated in patients with infection, DIC, or ARDS.
    • TF mRNA correlated with D-dimer, and GE-XDP correlated with leukocyte count and CRP in patients with DIC or ARDS.

    Conclusions:

    • Chemotherapy for lymphoma is associated with increased TF expression and inflammatory markers.
    • Inflammatory changes and thrombosis may lead to leukocyte activation during lymphoma treatment.
    • Understanding these mechanisms is crucial for managing complications like DIC and ARDS in lymphoma patients.