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Updated: Aug 15, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Pain treatment in patients on chronic opioid therapy and in drug abusers]
Ulf E Kongsgaard1, Rae Frances Bell, Harald Breivik
1Anestesiavdelingen, Det Norske Radiumhospital, Montebello, 0310 Oslo. u.e.kongsgaard@klinmed.uio.no
Background:
Substance abuse in pain management can undermine treatment compliance, the effectiveness of therapies, and social support and functioning.
Material:
An overview is given regarding pain management for patients on chronic use of opioids and for patients with drug dependence and substance abuse.
Results:
Clinical experience as well as relevant documentation demonstrates that management of these patients remains one of the most challenging problems in clinical medicine.
Conclusion:
Assessment and treatment plans for this patient group require an understanding of tolerance, physical dependence and drug abuse. It is imperative that the patient's ongoing treatment is planned in a multidisciplinary setting, so as to assure a consistent, structured and shared approach by all caregivers.
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