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Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer

Ugur Ozerdem1

  • 1La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA. ozerdem@ljimm.org

The Prostate
|October 26, 2005
PubMed
Abstract

Insights

Targeting NG2 on prostate cancer pericytes with a neutralizing antibody significantly reduced tumor neovascularization and lymphangiogenesis. This approach offers a promising strategy for inhibiting prostate cancer growth.

Area of Science:

  • Oncology
  • Vascular Biology
  • Cancer Research

Background:

  • Prostate cancer capillary walls involve endothelial cells and pericytes.
  • NG2, a proteoglycan on nascent pericytes, plays a role in neovascularization.

Purpose of the Study:

  • To investigate the anti-angiogenic and anti-lymphangiogenic effects of targeting pericyte-NG2 in prostate cancer models.

Main Methods:

  • Administered NG2 neutralizing antibody in hydron pellets to PC-3 and LNCaP xenografts.
  • Utilized NG2 knockout mice with TRAMP and TRAMP-C1 tumors for intrinsic pericyte targeting.
  • Quantified microvascular density (MVD) and lymphatic vascular density (LVD) via confocal microscopy.

Main Results:

  • NG2 antibody significantly reduced corneal neovascularization in PC3 and LNCaP xenografts.
  • NG2 knockout mice showed significantly lower MVD (71-63%) and LVD (73-84%) in TRAMP and TRAMP-C1 tumors compared to controls.

Conclusions:

  • Targeting pericyte-NG2 effectively decreases neovascularization and lymphangiogenesis in prostate cancer.
  • This strategy holds potential for therapeutic intervention in prostate cancer treatment.

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