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Updated: Aug 15, 2026
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
[Studies on hyaluronic acid as dendifier in Shuanghuanglian eye-drops]
Man-ling Ma1, Lu Liu, Shu-ying Sun
1First Hospital of Harbin Medical University, Harbin 150001, China. mamanling@54dr.com
Objective:
To study the possibility of hyaluronic acid as densifier of Shuanguangliao eye-drops.
Method:
The factors related with hyaluronic acid s viscosity, such as pH-value and storing temperature, are tested in this experiment. At the same time, we checked the stimulation, stability of the densifier.
Result:
There was not effect on viscosity of pH-value and storing temperature. No stimulation on the eye was found after densified with hyaluronic acid. The viscosity properties of hyaluronic acid are stablile.
Conclusion:
The hyaliuronic acid added to Shuanghuanglian eye-drops are stabiliable and it can be applied in eye-drops. The increased viscosity is benefit to extend the residence time of drug in eye.
