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Adipose tissue changes in obesity.

S W Coppack1

  • 1Barts and The London, Queen Mary's School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, UK. s.w.coppack@qmul.ac.uk

Biochemical Society Transactions
|October 26, 2005
PubMed
Summary
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Obesity causes numerous histological, neural, vascular, metabolic, and endocrine changes in adipose tissue. Future research should explore the reversibility and depot-specific differences of these obesity-related adipose tissue alterations.

Area of Science:

  • Adipose tissue biology
  • Obesity pathophysiology
  • Metabolic disease research

Background:

  • Obesity is characterized by significant alterations in adipose tissue.
  • These changes encompass histological, neural, vascular, metabolic, and endocrine functions.
  • The precise origins and importance of these adipose tissue modifications remain under investigation.

Purpose of the Study:

  • To provide a comprehensive overview of adipose tissue alterations in obesity.
  • To highlight the multifaceted nature of these changes, including cellular, metabolic, and functional aspects.
  • To identify key areas for future research in obesity and adipose tissue biology.

Main Methods:

  • Review of existing literature on adipose tissue in obesity.
  • Synthesis of findings related to histological, neural, vascular, and metabolic changes.

Related Experiment Videos

  • Analysis of endocrine functions and cellular expansion in obese adipose tissue.

    • Main Results:

    • Adipose tissue undergoes diverse changes in obesity, including altered histology, neural and vascular networks, and impaired lipid/carbohydrate metabolism.
    • Endocrine functions of adipose tissue are also affected, with potential origins in simple cell size and number expansion.
    • Current understanding suggests adipose tissue is relatively unresponsive to physiological regulation in daily life.

    Conclusions:

    • Obesity-induced changes in adipose tissue are widespread and complex.
    • Further research is needed to determine the most critical changes for intermediary metabolism and obesity comorbidities.
    • Key future questions involve the reversibility of these changes and potential depot- and species-specific differences.