Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Protein lipidation of BACE.

R B Parsons¹, B M Austen

¹Department of Basic Medical Sciences, St. George's University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK. r.parsons@sgul.ac.uk

Biochemical Society Transactions

|October 26, 2005

Summary

Protein lipidation of beta-secretase (BACE) is crucial for amyloid beta-protein (Abeta) production. This lipid modification promotes BACE dimerization, impacting Abeta generation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Parkinson's Disease Master Regulators on Substantia Nigra and Frontal Cortex and Their Use for Drug Repositioning.

Molecular neurobiology·2020

Same author

Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling.

Cell death & disease·2013

Same author

Protein-protein interactions in the assembly and subcellular trafficking of the BACE (beta-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease.

Biochemical Society transactions·2007

Same author

Regulation of the lipidation of beta-secretase by statins.

Biochemical Society transactions·2007

Same author

Structure and neurotoxicity of novel amyloids derived from the BRI gene.

Biochemical Society transactions·2005

Same author

Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica.

Molecular pathology : MP·2003

Area of Science:

Biochemistry
Neuroscience
Molecular Biology

Background:

The protein lipid modification of beta-site amyloid precursor protein cleaving enzyme (BACE) is not well understood.
BACE plays a critical role in the production of amyloid beta-protein (Abeta), a key component in Alzheimer's disease pathology.

Purpose of the Study:

To investigate the role of protein lipidation in BACE function.
To elucidate how lipidation affects BACE activity and Abeta production.

Main Methods:

The study focused on analyzing the lipid modification of BACE.
Investigated the impact of lipidation on BACE dimerization and Abeta generation.

Main Results:

Lipidation was found to influence the production of Abeta.
Lipidation promotes the dimerization of BACE, a key step in Abeta formation.

Conclusions:

Protein lipidation is an important regulatory mechanism for BACE activity.
Understanding BACE lipidation may offer new therapeutic targets for Alzheimer's disease.

Related Experiment Videos