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Updated: Aug 15, 2026

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
Published on: September 20, 2011
Imaging the cAMP-dependent signal transduction pathway
M Zaccolo1, T Cesetti, G Di Benedetto
1Dulbecco Telethon Institute at the Venetian Institute of Molecular Medicine, Via Orus 2, 35100 Padova, Italy. manuela.zaccolo@unipd.it
Abstract:
In recent years, the development of new technologies based on the green fluorescent protein and FRET (fluorescence resonance energy transfer) has introduced a new perspective in the study of cAMP signalling. Real-time imaging of fluorescent biosensors is making it possible to visualize cAMP dynamics directly as they happen in intact, living cells, providing important and original insights for our understanding of the spatiotemporal organization of the cAMP/PKA (protein kinase A) signalling pathway.
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