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Defining the protein-protein interactions of the mammalian endoplasmic reticulum oxidoreductases (EROs)
S Dias-Gunasekara1, A M Benham
1Department of Biological and Biomedical Sciences, University of Durham, South Road, Durham DH1 3LE, UK.
Abstract:
The ER (endoplasmic reticulum) is the site of protein folding for all eukaryotic secreted and plasma membrane proteins. Disulphide bonds are formed in many of these proteins through a dithiol-disulphide exchange chain comprising two types of protein catalysts: PDI (protein disulphide-isomerase) and ERO (ER oxidoreductase) proteins. This review will examine what we know about ERO function, and will then consider ERO interactions and their implications for mammalian oxidative protein folding.
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