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Related Concept Videos

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Jan 25, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
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Cancer stem cells: AMLs show the way.

D Bonnet1

  • 1Hematopoietic Stem Cell Laboratory, Cancer Research UK. dominique.bonnet@cancer.org.uk

Biochemical Society Transactions
|October 26, 2005
PubMed
Summary

Leukaemic stem cells (LSCs) drive leukemia, originating from normal blood stem cells. Understanding LSC development offers insights into cancer stem cells (CSCs) in solid tumors.

Area of Science:

  • Hematology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Leukemia was the first disease where cancer stem cells (CSCs), specifically leukaemic stem cells (LSCs), were identified.
  • The hematopoietic system provides a well-defined model for studying CSCs due to its established developmental hierarchy.
  • Leukemia is characterized by aberrant hematopoietic processes initiated by LSCs with self-renewal capacity.

Purpose of the Study:

  • To review current knowledge on the developmental origin and emergence mechanisms of LSCs.
  • To establish LSC development as a paradigm for identifying CSCs in solid tumors.

Main Methods:

  • Review of existing literature on LSC development and hematopoietic stem cell biology.
  • Analysis of mechanisms underlying LSC emergence, including mutations and epigenetic changes.

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Last Updated: Jan 25, 2026

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Main Results:

  • LSCs arise from accumulated mutations and/or epigenetic changes, enabling indefinite proliferation.
  • The well-defined hematopoietic hierarchy aids in understanding LSC origins.

Conclusions:

  • Further research into LSC development is crucial for understanding leukemia.
  • LSC biology provides a foundational model for the broader identification and study of cancer stem cells in solid tumors.