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Related Experiment Videos

Does increased arterial stiffness increase the risk for postural hypotension?

David Sengstock1, Peter V Vaitkevicius, Mark A Supiano

  • 1Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System, and the Geriatric Research, Education, and Clinical Center, Veterans Affairs Health Care System, Ann Arbor, MI 48105, USA. dsmd@umich.edu

The American Journal of Geriatric Cardiology
|October 26, 2005
PubMed
Summary

Increased arterial stiffness is not linked to postural hypotension in older adults. Instead, higher arterial stiffness correlated with a rise in systolic blood pressure (BP) upon standing, suggesting other factors influence BP regulation in aging.

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Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Hypertension Research

Background:

  • Arterial stiffness, a marker of vascular aging, is often associated with cardiovascular disease.
  • Postural hypotension, a drop in blood pressure upon standing, is common in older adults and can lead to falls.
  • The relationship between arterial stiffness and the body's blood pressure regulation during postural changes requires further investigation.

Purpose of the Study:

  • To test the hypothesis that increased arterial stiffness is associated with postural hypotension in older adults.
  • To examine the association between aortic pulse wave velocity and postural blood pressure response in healthy older adults.

Main Methods:

  • Assessed aortic pulse wave velocity and postural blood pressure response in 49 community-dwelling older adults (mean age 71 years).

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  • Participants included normotensive and hypertensive individuals not on vasoactive medications.
  • Blood pressure response was categorized based on systolic blood pressure changes during a 5-minute upright posture period.

    • Main Results:

    • Contrary to the hypothesis, higher pulse wave velocity was found in subjects with a postural increase in systolic BP compared to those with a decrease.
    • Aortic pulse wave velocity was significantly greater in subjects with no change or a postural increase in systolic BP than in those with a postural decrease <20 mm Hg (p=0.03).
    • Higher pulse wave velocity correlated with a more positive postural systolic BP response at 1, 3, and 5 minutes (p<0.024).

    Conclusions:

    • This study does not support a relationship between arterial stiffness and postural hypotension in healthy older adults.
    • Other age-related factors likely play a more significant role in regulating blood pressure homeostasis during postural changes.
    • Findings suggest a complex interplay of factors influencing blood pressure regulation in the elderly, beyond arterial stiffness alone.