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[Primary hyperoxaluria and pregnancy].

S Cimino1, S Ranno, M Garozzo

  • 1Dipartimento di Scienze della Senescenza, Urologiche e Neurourologiche, Catania, Italy.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology
|October 26, 2005
PubMed
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Pregnancy in women with primary hyperoxaluria type 1 poses significant risks. Increased calciuria and proteinuria during late pregnancy can endanger both mother and child, necessitating informed patient counseling.

Area of Science:

  • Nephrology
  • Maternal-Fetal Medicine
  • Genetics

Background:

  • Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder causing oxalate overproduction and deposition.
  • Pregnancy in PH1 patients presents unique challenges due to altered physiological states.
  • Limited data exists on pregnancy outcomes and maternal-fetal prognosis in PH1.

Observation:

  • A rare case of successful pregnancy in a PH1 patient is presented.
  • Significant alterations in hepatorenal function were observed during the third trimester.
  • Increased calciuria and proteinuria were noted, indicating heightened risk.

Findings:

  • The patient underwent a caesarean section at 36 weeks due to severe gestosis.
  • Kidney function did not improve postpartum, highlighting persistent disease impact.

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  • Pregnancy significantly stressed the maternal hepatorenal system.

    • Implications:

    • Pregnancy poses a substantial life risk to both PH1 patients and their newborns.
    • Close monitoring and proactive management are crucial for high-risk pregnancies.
    • Informing PH1 patients about pregnancy risks is essential for reproductive decision-making.