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[Conservative management of multicystic dysplastic kidney: clinical course and ultrasound outcome]
Eli Armando S Rabêlo1, Eduardo A Oliveira, José Maria Penido Silva
1Unidade de Nefrologia Pediátrica, Departamento de Cirurgia, Hospital das Clinicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Insights
Prenatally detected multicystic dysplastic kidney (MCDK) in children often involutes over time with conservative management. This approach is safe, with a low incidence of complications, and contralateral kidney growth is observed.
Area of Science:
- Pediatric Nephrology
- Fetal Medicine
- Diagnostic Ultrasound
Background:
- Multicystic dysplastic kidney (MCDK) is a common congenital anomaly.
- Prenatal detection allows for early monitoring and management strategies.
Purpose of the Study:
- To describe the clinical course and ultrasound outcomes of prenatally detected unilateral MCDK.
- To evaluate the safety and efficacy of conservative management for MCDK.
Main Methods:
- Retrospective analysis of 53 children with prenatally detected unilateral MCDK.
- Conservative management with regular clinical and ultrasound follow-up.
- Evaluation of blood pressure, UTI, renal function, growth, MCDK involution, and contralateral renal growth.
Main Results:
- 90% of MCDK cases showed involution, with 17% complete involution within 68 months follow-up.
- Low incidence of complications: 2/53 hypertension, 5/53 UTI.
- Significant compensatory hypertrophy of the contralateral kidney, particularly in the first 24 months.
Conclusions:
- Conservative management of prenatally detected MCDK is safe and effective.
- MCDK demonstrates a natural tendency to decrease in size (involute).
- Contralateral kidney compensatory growth is significant in early childhood.
Objective:
The aim of this study was to describe the clinical course and ultrasound outcome of prenatally detected multicystic dysplastic kidney.
Methods:
Fifty-three children with unilateral multicystic dysplastic kidney detected by prenatal ultrasound between 1989 and 2004 were included in the analysis. All children were submitted to conservative management with follow-up visits every six months. Follow-up ultrasound examinations were performed at six-month intervals during the first two years of life and yearly thereafter. The following clinical parameters were evaluated: blood pressure, urinary tract infection, renal function, and growth. The following ultrasound parameters were evaluated: involution of multicystic dysplastic kidney and contralateral renal growth.
Results:
The mean follow-up time was 68 months. Two children presented hypertension during follow-up and five had urinary tract infection (only one with recurrent episodes). There was no malignant degeneration of multicystic dysplastic kidney. A total of 334 ultrasound scans were analyzed. US scan demonstrated involution of the multicystic dysplastic kidney in 48 (90%) cases, including complete involution in nine (17%). The involution rate was faster in the first 30 months of life. There was progressive compensatory renal hypertrophy of the contralateral renal unit; the rate of growth was greater in the first 24 months of life.
Conclusion:
The results of prolonged follow-up of children with conservatively managed multicystic dysplastic kidney suggest that clinical approach is safe, the incidence of complications is small, and that there is a clear tendency for multicystic dysplastic kidney to decrease in size. Our data also suggest that the involution rate of multicystic dysplastic kidney as well as the growth of the contralateral kidney is greater in the first 24 months of life.
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