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Related Experiment Videos

Treatment resistant depression in the elderly: three cases.

J Seymour1, J P Wattis

  • 1Rosemary Day Hospital, St. James's University Hospital, Leeds, UK.

International Clinical Psychopharmacology
|January 1, 1992
PubMed
Summary
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Severe depression cases contraindicated for electroconvulsive therapy (ECT) showed dramatic improvement by switching from lithium and fluoxetine to lithium and lofepramine, suggesting a new treatment option.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Electroconvulsive therapy (ECT) is a common treatment for severe depression.
  • Lithium and fluoxetine is a common treatment regimen for depression.

Observation:

  • Three patients with severe depression had contraindications for ECT.
  • These patients were treated with lithium and fluoxetine.

Findings:

  • Switching treatment from lithium and fluoxetine to lithium and lofepramine resulted in dramatic improvement in all three patients.
  • This suggests lofepramine may be an effective alternative in specific cases.

Implications:

  • Lofepramine could be a viable alternative for patients with severe depression when ECT is contraindicated.
  • Further research into the mechanisms of lithium and lofepramine interaction is warranted.

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