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Application of glycine in acute alcohol hallucinosis
Nadir A Aliyev1, Zafar N Aliyev
1Dispensary of Mental Hygiene, Azerbaijan Republic.
Introduction:
Previous studies showed that patients with acute alcohol hallucinosis had significantly lower levels of the inhibitory amino acid neurotransmitter, glycine.
Methods:
A placebo-controlled, double-blind study of glycine in 40 patients with acute alcohol hallucinosis. Treatment duration was 7 days with no other psychotropic medication.
Results:
The 20 patients randomised to the active drug (700 mg glycine sublingually) demonstrated a significant decrease in severity of hallucinosis compared to the 20 patients receiving placebo.
Conclusion:
The positive effects of glycine may be related to an altered balance between excitatory and inhibitory amino acid neurotransmitters.
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