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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Effects of acrolein on the quadruplex forming d(TTAGGG)4 telomeric repeat sequence
Nicola Borbone1, Giuliana D'Isa, Giorgia Oliviero
1Dipartimento di Chimica delle Sostanze Naturali, University of Naples, Faculty of Pharmacy, via Domenico Montesano 49, Napoli 80131, Italy. borbone@unina.it
Nucleosides, Nucleotides & Nucleic Acids
|October 27, 2005
Abstract:
HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TITAGGG)4 human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.
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