Stereoselective synthesis of conformationally rigid apio carbanucleosides as potential antiviral agents
Hyung Ryong Moon1, Kyung Ran Kim, Bum Tae Kim
1College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Nucleosides, Nucleotides & Nucleic Acids
|October 27, 2005
Abstract:
Apio north-methanocarbocyclic nucleosides 1-3 with bicyclo[3. 1.0]hexane template were first synthesized. Introduction of hydroxymethyl substituent was efficiently and stereoselectively accomplished by aldol and retro-aldol reaction and fixed conformation was achieved from a modified Simmons-Smith cyclopropanation on a cyclopentane ring.
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