Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines
A A Pchelintseva1, M V Skorobogatyj, A L Petrunina
1Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Nucleosides, Nucleotides & Nucleic Acids
|October 27, 2005
Abstract:
Eight 5-alkynyl-2'deoxyuridines containing different bulky substituents have been prepared and tested against HSV-1 in Vero cells. The compounds show positive antiviral activity. There is no obvious correlation between activity and substituent size. The nature of the linker between uracil and a substituent appears to be more important for antiviral properties: nucleosides containing arylethynyl groups show higher activity.
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