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Updated: Aug 15, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
Published on: April 12, 2019
Enzymatic resolution and base pairing properties of D- and L-cyclohexenyl nucleic acids (CeNA)
Ping Gu1, Guy Schepers, Carsten Griebel
1Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium.
Abstract:
An enzymatic transesterification reaction afforded large scale resolution of the cyclohexenol precursor needed for preparation of both series of CeNA building blocks. CeNA oligos of "D-like" chirality display a strong and selective interaction with RNA, while preserving RNase H activity, and therefore have potential as antisense constructs. CeNAs of opposite chirality form a self-pairing system on their own.
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