Synthesis study of 3'-alpha-fluoro-2',3'-dideoxyguanosine
Takayoshi Torii1, Tomoyuki Onishi, Shigehisa Tanji
1AminoScience Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
Nucleosides, Nucleotides & Nucleic Acids
|October 27, 2005
Abstract:
A synthetic method was established for 3'-alpha-fluoro-2','3-dideoxyguanosine 1 from guanosine 2 in 27% overall yield and 6 steps. A byproduct 6a of fluorination was identified by NMR studies, its presence strongly supporting our supposition that the fluorination itself proceeded via a bromonium cation.
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