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Updated: Aug 15, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

Technology evaluation: VEGF Trap (cancer), Regeneron/sanofi-aventis

Sin C Lau1, Daniela D Rosa, Gordon Jayson

  • 1Cancer Research UK, Department of Medical Oncology, Christie Hospital, Withington, Manchester, UK.

Current Opinion in Molecular Therapeutics
|October 27, 2005
PubMed

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...