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Updated: Aug 15, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
[Immune dysregulation mediated by hepatitis C virus infection]
1School of Health, Faculty of Medicine, Tohoku University, 2-1, Seiryoumachi, aobaku, Sendaishi 980-8575, Japan. kobakoju@mail.tains.tohoku.ac.jp
Abstract:
Hepatitis C virus, which is non-cytopathic, establishes persistent infection in majority of patients after acute infection, causing various degrees of clinical liver disease. To escape and survive, hepatitis C virus may take ingenious strategies. Hepatitis C virus gene products interact host proteins to evade host immune responses in addition to the appearance of quasispecies. Against hepatitis C virus infection, host may avoid extensive tissue damage by inducing the activity of regulatory T cells. Insights into this mechanism of immune regulation may help to future development of novel therapies against hepatitis C virus.
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