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Initial experience with X-ray CT based attenuation correction in myocardial perfusion SPECT imaging using a combined
Daisuke Utsunomiya1, Seiji Tomiguchi, Shinya Shiraishi
1Diagnostic Imaging Center, Saiseikai Kumamoto Hospital, 5-3-1 Chikami, Kumamoto 861-4193, Japan. d-utsunomiya@skh.saiseikai.or.jp
Annals of Nuclear Medicine
|October 27, 2005
Summary
X-ray CT based attenuation correction (AC) significantly improved diagnostic accuracy in myocardial perfusion imaging. This technique enhances specificity, showing potential as a reliable clinical tool for detecting coronary artery disease.
Area of Science:
- Nuclear Medicine
- Radiology
- Cardiology
Background:
- Attenuation artifacts in myocardial perfusion imaging reduce diagnostic accuracy.
- X-ray CT based attenuation correction (AC) is a potential solution.
Purpose of the Study:
- To assess the clinical usefulness of X-ray CT based AC in myocardial SPECT imaging.
- To compare AC- and non-corrected (NC) SPECT images against coronary angiography (CAG).
Main Methods:
- Retrospective review of 30 patients' myocardial SPECT/CT images.
- Two readers assessed SPECT images for coronary artery disease (CAD) presence.
- Comparison of diagnostic performance between AC- and NC-SPECT images.
Main Results:
- AC-SPECT images showed statistically significant improvements in overall diagnostic accuracy.
- Sensitivity/specificity/accuracy for AC-images were 76%/93%/89% versus 67%/86%/81% for NC-images.
- Interobserver agreement was substantial to almost perfect for both AC- and NC-images.
Conclusions:
- X-ray CT based AC significantly increased diagnostic accuracy, primarily due to improved specificity.
- This technique shows potential as a reliable clinical tool for myocardial SPECT imaging.