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Updated: Aug 15, 2026

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis
Published on: August 17, 2022
["Can high fluid intake prevent cerebral and myocardial infarction?" Systematic review]
Kikuo Okamura1, Yukihiko Washimi, Hidetoshi Endo
1Department of Urology, National Center Hospital for Geriatrics and Gerontology.
Insights
High fluid intake may help reduce blood viscosity, a factor in cerebral and myocardial infarction. However, current evidence does not confirm that increased water consumption prevents these ischemic events.
Area of Science:
- Cardiovascular Science
- Neurology
- Public Health
Background:
- Cerebral and myocardial infarction are significant causes of morbidity and mortality.
- Atherosclerosis and atheroma plaque are primary etiological factors.
- Blood viscosity and dehydration are implicated as contributing factors.
Purpose of the Study:
- To systematically review the evidence on whether high fluid intake can prevent cerebral and myocardial infarction.
- To explore the relationship between fluid intake, blood viscosity, and ischemic events.
Main Methods:
- Systematic review of previously published papers.
- Searched PubMed using keywords related to dehydration, hydration, fluid intake, cerebral infarction, myocardial infarction, blood viscosity, and hemorheology.
- Included 22 selected studies of various designs (randomized, non-randomized, epidemiologic, retrospective).
Main Results:
- Dehydration increases blood viscosity, a potential cause of cerebral or myocardial infarction.
- Factors other than dehydration can also increase blood viscosity.
- No direct evidence shows high fluid intake prevents cerebral infarction, though night-time drinking may reduce viscosity.
- One report suggested a lower myocardial infarction risk in individuals drinking >5 glasses of water daily compared to <2.
Conclusions:
- Lifestyle adjustments are crucial for preventing cerebral and myocardial infarction due to underlying atherosclerosis.
- Direct evidence linking high fluid intake to prevention of cerebral infarction via viscosity reduction is lacking.
- Further research is needed on fluid intake and ischemic diseases, especially for the elderly to enhance quality of life.
Objectives:
We performed a systematic review about whether high fluid intake can prevent cerebral and myocardial infarction.
Materials And Methods:
Previously published papers were searched for in PubMed using the combined terms of dehydration, hydration, water intake, fluid intake, cerebral infarction, cerebrovascular disease, apoplexy, myocardial infarction, angina pectoris, ischemic heart disease, blood viscosity and hemorheology.
Results:
Of 611 papers searched, twenty-two were selected. There was one prospective randomized study, four prospective non-randomized studies, eight epidemiologic (cohort or case-control) studies and nine retrospective descriptive studies, presenting the following points. Dehydration, which increases blood viscosity, is one of the causes of cerebral or myocardial infarction. Important factors other than dehydration can cause an increase in viscosity. Drinking water during the night can protect an increase in blood viscosity but there has been no evidence that drinking excessive amount of water prevents cerebral infarction. There was one report that the risk of myocardial infarction was lower in people drinking more than 5 glasses of water than those drinking less than 2.
Conclusion:
Since cerebral and myocardial infarction are primarily caused by atherosclerosis and atheroma plaque, it is essential to adjust life style for prophylaxis. There has been no direct evidence that decrease in viscosity due to high fluid intake can prevent cerebral infarction. Further studies regarding the relationship between fluid intake and ischemic diseases, and the appropriate fluid intake for the elderly to improve their QoL are needed.
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