A strategy for the development of small-molecule-based sensors that strongly fluoresce when bound to a specific RNA

Brian A Sparano1, Kazunori Koide

  • 1Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.

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Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Riboswitches01:56

Riboswitches

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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RNA-seq03:21

RNA-seq

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Reporter Genes02:11

Reporter Genes

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Commonly used reporter...
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Translational Regulation

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