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Updated: Aug 15, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)

Na Kyung Lee1, Soo Young Lee

  • 1Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, Seoul 120-750, Korea.

Journal of Biochemistry and Molecular Biology
|October 27, 2005
PubMed

Insights

Tumor necrosis factor receptor-associated factors (TRAFs) are adapter proteins crucial for cell signaling. They link receptors to pathways controlling cell survival and death, influencing apoptosis and NF-kappaB activation.

Area of Science:

  • Cell biology
  • Molecular signaling
  • Immunology

Background:

  • Tumor necrosis factor receptor-associated factors (TRAFs) are key adapter proteins.
  • TRAFs connect cell surface receptors, including TNF and IL-1 superfamilies, to intracellular signaling pathways.
  • These pathways regulate critical cellular processes such as NF-kappaB activation and mitogen-activated protein kinase cascades.

Purpose of the Study:

  • To elucidate the role of TRAF proteins in mediating signals from cell surface receptors.
  • To understand how TRAF-mediated signaling influences cell survival and death pathways.
  • To investigate the interaction of TRAFs with proteins involved in receptor-induced apoptosis.

Main Methods:

  • Analysis of protein-protein interactions.
  • Investigation of signaling cascades.
  • Studies on receptor-mediated cell death and survival.

Main Results:

  • TRAF proteins act as crucial adaptors, linking various receptors to signaling cascades.
  • TRAF-mediated signals activate key pathways like NF-kappaB and MAP kinases.
  • TRAFs interact with proteins that regulate apoptosis, potentially promoting cell survival or inhibiting death receptor signaling.

Conclusions:

  • TRAF proteins play a central role in integrating receptor signals to control cell fate.
  • TRAF-mediated signaling influences the balance between cell survival and apoptosis.
  • Understanding TRAF function is critical for comprehending immune responses and cellular homeostasis.

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