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Updated: Aug 15, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles
Ana Castro1, Tania Castaño, Arantxa Encinas
1Instituto de Química Médica (CSIC), Juan de la Cierva 3, Madrid, Spain.
Abstract:
Chemical properties of 1,2,4-thiadiazole have been reviewed in the last few years. However, the usefulness of 1,2,4-thiadiazole as a privileged system in medicinal chemistry has prompted the advances on the therapeutic potential of this system. This review provides a brief summary of the medicinal chemistry of 1,2,4-thiadiazole system and highlights some examples of 1,2,4-thiadiazole-containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 1,2,4-thiadiazole is presented in sections by generalized synthetic methods.
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