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Advances in prodrug design
Antonio Távora de Albuquerque Silva1, Man Chin Chung, Lúcia Fioravanti Castro
1Laboratório de Pesquisa e Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciencias Farmacee, UNESP, Araraquara, Brazil.
Mini Reviews in Medicinal Chemistry
|October 28, 2005
Summary
This study reviews advanced prodrug design, focusing on polymer and macromolecule carriers for latent systems. It introduces various targeted therapies like Polymer-Directed Enzyme Prodrug Therapy (PDEPT) and Antibody-Directed Enzyme Prodrug Therapy (ADEPT).
Area of Science:
- Drug Delivery
- Polymer Science
- Biotechnology
Background:
- Prodrug design is crucial for developing advanced latent therapeutic systems.
- Polymers and macromolecules offer versatile carrier capabilities for prodrugs.
- Existing prodrug strategies leverage targeted delivery mechanisms.
Purpose of the Study:
- To present the background of prodrug design.
- To introduce new and advanced latent systems using macromolecular carriers.
- To briefly describe various polymer-based and targeted prodrug therapies.
Main Methods:
- Literature review of prodrug design principles.
- Overview of macromolecular and polymer-based carrier systems.
- Description of specific prodrug therapy examples and their mechanisms.
Main Results:
- Established the foundation for advanced prodrug design using versatile carriers.
- Introduced and briefly described Polymer-Directed Enzyme Prodrug Therapy (PDEPT), Polymer-Enzyme Liposome Therapy (PELT), Chemical Delivery System (CDS), Antibody-Directed Enzyme Prodrug Therapy (ADEPT), Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy (GDEPT/VDEPT), Osteotropic Drug Delivery System (ODDS), and Lectin-directed enzyme-activated prodrug therapy (LEAPT).
- Provided examples illustrating the application of these systems.
Conclusions:
- Macromolecules and polymers are key components in advanced prodrug design.
- Various targeted prodrug therapies offer diverse strategies for drug delivery.
- The described systems represent significant advancements in latent therapeutic systems.