Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates
Zhifang Xie1, Noman Siddiqi, Eric J Rubin
1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
Antimicrobial Agents and Chemotherapy
|October 28, 2005
Abstract:
We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.

